The Kraken Wakes: induced EMT as a driver of tumour aggression and poor outcome

摘要: Epithelial mesenchymal transition (EMT) describes the shift of cells from an epithelial form to a contact independent, migratory, form. In cancer change is linked invasion and metastasis. Tumour conditions, including hypoxia, acidosis range treatments can trigger EMT, which implicated in subsequent development resistance those same treatments. Consequently, degree EMT occurs may underpin entire course tumour progression treatment response patient. this review we look past protective effect against initial treatment, role state, once triggered, promoting disease growth, spread future insensitivity. patients correlation was found between propensity induce failure that provide survival benefit, implicating induction accelerated after cessation. Looking mechanisms driving detrimental effect; increased proliferation, suppressed apoptosis, stem cell induction, augmented angiogenesis, enhanced metastatic dissemination, immune tolerance, all result treatment-induced could worsen outcome. Evidence also suggests with earlier therapies attenuates benefits later beyond tumours, de-differentiation has therapy-attenuating effects reversal thereof yield similar rewards. A potential are address diverse molecular control systems involved EMT-induced progression. Considering broad reaching identified, successful deployment such substantially improve patient outcomes.