Adjuvant therapy reduces the benefit of palliative treatment in disseminated breast cancer - own findings and review of the literature.

摘要: Background: Adjuvant treatment concepts have improved the 10-year cure rate of breast and colon cancer, but new treatments for metastatic disease yielded only incremental benefit. If disseminated cancer were actually prolonging life rather than increasing remission rates, this effect should been documented over last 30+ years. However, published data concerning advances in contradictory. Patients Methods: To add data-based information, we analyzed 2 sources: a regional population-based registry (Hamburgisches Krebsregister, HKR), research (Projektgruppe Internistische Onkologie, PIO). We compared survival several thousand patients with who received after dissemination that initial adjuvant therapy. Results: After treatment, is up to third shorter without Conclusions: In accordance evidence, conclude ineffective shortens documentation disease. This probably due elimination chemo-sensitive tumor cells or induction resistance remaining micrometatases. negative on has shown clearly also probable other sites.