Multiple opiate receptors: emerging concepts.

摘要: Abstract Increasing biochemical evidence indicates that the wide spectrum of opiate pharmacological actions are mediated via heterogeneous classes receptors. μ receptors have been identified as high affinity sites where morphine-like opiates exert their analgesic effects. δ a somewhat different CNS distribution and relatively selective for naturally occuring enkephalins. Recent studies provide two additional receptor which were originally proposed on basis physiological studies. Ketocyclazocine-like produce unique ataxic sedative effects interaction with K receptors, SKF-10,047 (N-allylnorcyclazocine) related stimulant psychotomimetic interactions σ Many drugs interact at multiple sites. Thus, constellation neuropharmacological particular opioid ligand may reflect its various potencies combination μ, δ, K,