Differential regulation of extracellular matrix proteoglycan (PG) gene expression. Transforming growth factor-beta 1 up-regulates biglycan (PGI), and versican (large fibroblast PG) but down-regulates decorin (PGII) mRNA levels in human fibroblasts in culture.
作者： V.M. Kähäri , H. Larjava , J. Uitto
DOI: 10.1016/S0021-9258(18)99267-7
关键词:
摘要: … molecular mass of decorin appeared to be increased by about 20 kDa in TGF-Dl-… increased by incubation with TGF-Dl (Fig. 5A). The synthesis of versican was also stimulated by TGF-01 …
sci-hub.st 参考文章(49)
J Heino, V M Kähäri, A Mauviel, T Krusius, Human recombinant interleukin-1 regulates cellular mRNA levels of dermatan sulphate proteoglycan core protein. Biochemical Journal. ,vol. 252, pp. 309- 312 ,(1988) , 10.1042/BJ2520309
J Varga, J Rosenbloom, S A Jimenez, Transforming growth factor β (TGFβ) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts Biochemical Journal. ,vol. 247, pp. 597- 604 ,(1987) , 10.1042/BJ2470597
D. R. Edwards, G. Murphy, J. J. Reynolds, S. E. Whitham, A. J. Docherty, P. Angel, J. K. Heath, Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. The EMBO Journal. ,vol. 6, pp. 1899- 1904 ,(1987) , 10.1002/J.1460-2075.1987.TB02449.X
M L Chu, W de Wet, M Bernard, F Ramirez, Fine structural analysis of the human pro-alpha 1 (I) collagen gene. Promoter structure, AluI repeats, and polymorphic transcripts. Journal of Biological Chemistry. ,vol. 260, pp. 2315- 2320 ,(1985) , 10.1016/S0021-9258(18)89556-4
D.R. Zimmermann, E. Ruoslahti, Multiple domains of the large fibroblast proteoglycan, versican. The EMBO Journal. ,vol. 8, pp. 2975- 2981 ,(1989) , 10.1002/J.1460-2075.1989.TB08447.X
M Noda, K Yoon, C W Prince, W T Butler, G A Rodan, Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type beta transforming growth factor. Journal of Biological Chemistry. ,vol. 263, pp. 13916- 13921 ,(1988) , 10.1016/S0021-9258(18)68331-0
E Ruoslahti, Proteoglycans in cell regulation. Journal of Biological Chemistry. ,vol. 264, pp. 13369- 13372 ,(1989) , 10.1016/S0021-9258(18)80001-1
G Liau, L M Chan, Regulation of extracellular matrix RNA levels in cultured smooth muscle cells. Relationship to cellular quiescence. Journal of Biological Chemistry. ,vol. 264, pp. 10315- 10320 ,(1989) , 10.1016/S0021-9258(18)81802-6
A Bassols, J Massagué, Transforming growth factor beta regulates the expression and structure of extracellular matrix chondroitin/dermatan sulfate proteoglycans. Journal of Biological Chemistry. ,vol. 263, pp. 3039- 3045 ,(1988) , 10.1016/S0021-9258(18)69173-2
R A Ignotz, T Endo, J Massagué, Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta. Journal of Biological Chemistry. ,vol. 262, pp. 6443- 6446 ,(1987) , 10.1016/S0021-9258(18)48258-0