On the Selection of a Tracer for PET Imaging of HER2-Expressing Tumors: Direct Comparison of a 124I-Labeled Affibody Molecule and Trastuzumab in a Murine Xenograft Model

作者: A. Orlova , H. Wallberg , S. Stone-Elander , V. Tolmachev

DOI: 10.2967/JNUMED.108.057919

关键词:

摘要: Human epidermal growth factor receptor type 2 (HER2) is a tyrosine kinase, which often overexpressed in many carcinomas. Imaging HER2 expression malignant tumors can provide important prognos ...

参考文章(41)
Trastuzumab and breast cancer. The New England Journal of Medicine. ,vol. 345, pp. 995- 996 ,(2001) , 10.1056/NEJM200109273451312
Jörgen Carlsson, EGFR-Family Expression and Implications for Targeted Radionuclide Therapy Targeted Radionuclide Tumor Therapy. pp. 25- 58 ,(2008) , 10.1007/978-1-4020-8696-0_3
Gregory P. Adams, Torgny Stigbrand, Jörgen Carlsson, Targeted Radionuclide Tumor Therapy : Biological Aspects Springer. ,(2008)
E. Dijkers, M. N. Lub-de Hooge, J. G. Kosterink, P. L. Jager, A. H. Brouwers, L. R. Perk, G. A. van Dongen, E. G. de Vries, Characterization of 89Zr-trastuzumab for clinical HER2 immunoPET imaging Journal of Clinical Oncology. ,vol. 25, pp. 3508- 3508 ,(2007) , 10.1200/JCO.2007.25.18_SUPPL.3508
Anna Orlova, Joachim Feldwisch, Lars Abrahmsén, Vladimir Tolmachev, Update: Affibody Molecules for Molecular Imaging and Therapy for Cancer Cancer Biotherapy and Radiopharmaceuticals. ,vol. 22, pp. 573- 584 ,(2007) , 10.1089/CBR.2006.004-U
Helena Wållberg, Anna Orlova, Slow Internalization of Anti-HER2 Synthetic Affibody Monomer 111In-DOTA-ZHER2:342-pep2 : Implications for Development of Labeled Tracers Cancer Biotherapy and Radiopharmaceuticals. ,vol. 23, pp. 435- 442 ,(2008) , 10.1089/CBR.2008.0464
Rafael Molina, Vivian Barak, Arie van Dalen, Michael J. Duffy, Roland Einarsson, Massimo Gion, Helena Goike, Rolf Lamerz, Marius Nap, György Sölétormos, Petra Stieber, Tumor markers in breast cancer- European Group on Tumor Markers recommendations. Tumor Biology. ,vol. 26, pp. 281- 293 ,(2005) , 10.1159/000089260
Ying Tang, Judy Wang, Deborah A. Scollard, Hridya Mondal, Claire Holloway, Harriette J. Kahn, Raymond M. Reilly, Imaging of HER2/neu-positive BT-474 human breast cancer xenografts in athymic mice using 111In-trastuzumab (Herceptin) Fab fragments Nuclear Medicine and Biology. ,vol. 32, pp. 51- 58 ,(2005) , 10.1016/J.NUCMEDBIO.2004.08.003
Ann-Charlott Steffen, Maria Wikman, Vladimir Tolmachev, Gregory P. Adams, Fredrik Y. Nilsson, Stefan Ståhl, Jörgen Carlsson, In Vitro Characterization of a Bivalent Anti-HER-2 Affibody with Potential for Radionuclide-Based Diagnostics Cancer Biotherapy and Radiopharmaceuticals. ,vol. 20, pp. 239- 248 ,(2005) , 10.1089/CBR.2005.20.239