Inhibitor of human collagenase from cultures of human tendon.
作者： C L Mainardi , C A Vater , E D Harris
DOI: 10.1016/S0021-9258(17)30180-1
关键词:
摘要: A potent inhibitor of human collagenases, released from tendon explants in culture, has been purified and partially characterized. The an estimated molecular weight 25,000. It is relatively heat-stable but undergoes loss activity following exposure to trypsin. inhibits trypsin-activated rheumatoid synovial collagenase as well the enzyme obtained polymorphonuclear leukocytes. No inhibition Clostridium histolyticum (clostridiopeptidase A, EC 3.4.24.3) was noted. This may be a factor regulation extracellular connective tissue catabolism.
sci-hub.st 参考文章(39)
David M. Neville, Hartmut Glossmann, [9] Molecular weight determination of membrane protein and glycoprotein subunits by discontinuous gel electrophoresis in dodecyl sulfate Methods in Enzymology. ,vol. 32, pp. 92- 102 ,(1974) , 10.1016/0076-6879(74)32012-5
Jerome Gross, David Kirk, The Heat Precipitation of Collagen from Neutral Salt Solutions: Some Rate-Regulating Factors Journal of Biological Chemistry. ,vol. 233, pp. 355- 360 ,(1958) , 10.1016/S0021-9258(18)64764-7
Zena Werb, Mary C. Burleigh, Alan J. Barrett, Phyllis M. Starkey, The interaction of α2-macroglobulin with proteinases. Binding and inhibition of mammalian collagenases and other metal proteinases Biochemical Journal. ,vol. 139, pp. 359- 368 ,(1974) , 10.1042/BJ1390359
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
A Sellers, E Cartwright, G Murphy, J J Reynolds, Evidence that latent collagenases are enzyme-inhibitor complexes. Biochemical Journal. ,vol. 163, pp. 303- 307 ,(1977) , 10.1042/BJ1630303
Alan J. Barrett, Phyllis M. Starkey, The interaction of α2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism Biochemical Journal. ,vol. 133, pp. 709- 724 ,(1973) , 10.1042/BJ1330709
J. M. Jones, J. M. Creeth, R. A. Kekwick, Thiol reduction of human α2-macroglobulin. The subunit structure Biochemical Journal. ,vol. 127, pp. 187- 197 ,(1972) , 10.1042/BJ1270187
Paul J. Birckbichler, Henry A. Carter, Gerald R. Orr, E. Conway, M.K. Patterson, ε-(γ-Glutamyl)lysine isopeptide bonds in normal and virus transformed human fibroblasts Biochemical and Biophysical Research Communications. ,vol. 84, pp. 232- 237 ,(1978) , 10.1016/0006-291X(78)90287-5
J. Dayer, R Graham, G Russell, S. Krane, Collagenase Production by Rheumatoid Synovial Cells: Stimulation by a Human Lymphocyte Factor Science. ,vol. 195, pp. 181- 183 ,(1977) , 10.1126/SCIENCE.188134
Zena Werb, Carlo L. Mainardi, Carol A. Vater, Edward D. Harris, Endogenous activation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator. The New England Journal of Medicine. ,vol. 296, pp. 1017- 1023 ,(1977) , 10.1056/NEJM197705052961801