Cytonemes Versus Neutrophil Extracellular Traps in the Fight of Neutrophils with Microbes.

摘要: Neutrophils can phagocytose microorganisms and destroy them intracellularly using special bactericides located in intracellular granules. Recent evidence suggests that neutrophils catch kill pathogens extracellularly the same bactericidal agents. For this, live create a cytoneme network, dead provide chromatin proteins to form neutrophil extracellular traps (NETs). Cytonemes are filamentous tubulovesicular secretory protrusions of living with intact nuclei. Granular localized membrane vesicles tubules which cytonemes composed. NETs strands decondensed DNA associated histones released by died neutrophils. In NETs, neutrophilic agents adsorbed onto not covered membrane. occupy different places protecting body against infections. develop within few minutes at site infection through action nitric oxide or actin-depolymerizing alkaloids invading microbes. The formation NET vitro occurs due decondensation resulting from prolonged activation PMA (phorbol 12-myristate 13-acetate) other stimuli, vivo citrullination peptidylarginine deiminase 4. addition antibacterial activity, involved cell adhesion communications. play role autoimmunity thrombosis.