Microglia-Derived Microvesicles Affect Microglia Phenotype in Glioma.

摘要: Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring ready to use box information, consisting proteins, lipids nucleic acids. In the nervous system, EVs participate neuron-glial cross-talk, bidirectional communication important preserve brain homeostasis and, when dysfunctional, involved in several CNS diseases. We investigated whether microglia-derived could be used transfer protective phenotype dysfunctional microglia context tumor. When MV, isolated from stimulated with LPS/IFNγ were injected glioma-bearing mice, we observed switch tumor associated myeloid cells (TAMs) reduction size. Our findings indicate that MV cargo, which contains upregulated transcripts for inflammation-related genes, can information glioma bearing mice modifying microglial gene expression, reducing neuronal death invasion, thus promoting recovery homeostasis.