Cardiovascular Effects of Ophthalmic Timolol

摘要: We studied cardiovascular effects related to ophthalmic timolol maleate, a beta-adrenergic blocker commonly used treat chronic glaucoma. Twenty normal subjects were randomly assigned two double-blind treatment groups each with ten subjects. One group received drops of (0.5%) twice daily for 4 weeks, and the other placebo (artificial tears) weeks. Ophthalmic significantly decreased resting maximal exercise heart rate after first dose during dosing. Chronic administration reduced oxygen consumption at blunted augmentation in capacity seen therapy. Cardiac sympathetic tone inotropy treatment. Despite presence drug-induced effects, plasma levels often undetectable never exceeded 2.8 ng/mL.