Itraconazole vs. trimethoprim–sulfamethoxazole: a comparative cohort study of 200 patients with paracoccidioidomycosis

摘要: Paracoccidioidomycosis (PCM) is a systemic mycosis endemic to Latin America. Brazil accounts for approximately 80% of cases, where it represents major public health issue due its disabling impact and the number premature deaths causes. We present retrospective cohort study that was conducted in order better understand factors relate cure infection treatment 200 patients with PCM. evaluated influence sociodemographic clinical as well therapeutic regimen (trimethoprim-sulfamethoxazole [TMP-SMX] itraconazole) on progress PCM (cure noncure). There higher incidence (83%) among who regularly received their infections completed protocol. Moreover, itraconazole (86.4%) significantly superior TMP-SMX (51.3%) terms rate had median period shorter (12 months) than (23 months). A Cox proportional hazard regression model showed use increased cure, regardless sex, age, education, form, completion treatment, regularity. Although results this show best option patients, double-blind, randomized, controlled trial necessary confirm conclusion.