Four Foodborne Disease Outbreaks Caused by a New Type of Enterotoxin-Producing Clostridium perfringens

摘要: The epidemiological and bacteriological investigations on four foodborne outbreaks caused by a new type of enterotoxin-producing Clostridium perfringens are described. C. isolated from patients these did not produce any known enterotoxin carry the gene. However, culture filtrates isolates induced accumulation fluid in rabbit ileal loop tests. molecular weight may be between 50,000 100,000, although is ca. 35,000. This was heat labile, its biological activities were inactivated heating for 5 min at 60°C. sensitive to pH values higher than 11.0 protease treatment but resistant trypsin treatment. These results suggest that protein. Although morphological changes Vero cells, differed those enterotoxin. also L929 whereas not, because cells lacked an appropriate receptor. recognized as only diarrheagenic toxin responsible outbreaks, present study indicate produced