Leiomyoma and vascular endothelial growth factor gene polymorphisms: a systematic review.
作者： Chi-Chen Chang , Yao-Yuan Hsieh , Wen-Hsin Lin , Chih-Sheng Lin
DOI: 10.1016/S1028-4559(10)60056-3
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摘要: Summary Leiomyomas (myoma or fibroid) are the most common gynecologic tumors that occur in women of reproductive age, but their molecular pathogenesis is still unknown. Since growth leiomyomas involve numerous vascular factors, an association between leiomyoma and factors suspected. Vascular endothelial factor (VEGF) one important angiogenic factors. VEGF regulates angiogenesis mediates sex steroid-induced cell differentiation. VEGF-mediated activities seem to contribute leiomyoma. Genetic variations, including polymorphisms, might also be associated with complex leiomyomas. Here, we performed a systematic review roles its polymorphisms
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