Modulation of NMDA receptor function as a treatment for schizophrenia.

摘要: Abstract Schizophrenia is a devastating mental illness that afflicts nearly 1% of the world’s population. Currently available antipsychotics treat positive symptoms, but are largely ineffective at addressing negative symptoms and cognitive dysfunction. Thus, improved pharmacotherapies all aspects disease remain critical unmet need. There mounting evidence links NMDA receptor hypofunction expression schizophrenia, numerous drug discovery programs have developed agents directly or indirectly potentiate receptor-mediated neurotransmission. Several compounds emerged show promise for treating symptom sub-domains in both preclinical models clinical studies, we will review recent developments many these areas.