Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin.

摘要: Community-acquired (CA) methicillin-resistant Staphylococcus aureus (MRSA) infection among individuals without healthcare-associated (HA) risk factors was first recognized about a decade ago. It has now emerged as an epidemic that is responsible for rapidly progressive, fatal diseases including necrotizing pneumonia, severe sepsis and fasciitis. Unlike HA-MRSA, CA-MRSA are usually pan-susceptible to non-beta-lactam antimicrobials. In addition novel methicillin resistance genetic cassettes, many harbor phage harboring Panton-Valentine Leukocidin (PVL) genes some data support the idea PVL at least in part increased virulence of CA-MRSA. The tight association between cassettes cannot be explained, they integrate into distinct sites on S. chromosome. This paper presents evidence isolates strains emerging de novo from CA-methicillin susceptible rather than HA-MRSA have escaped hospital setting these may more virulent HA-MRSA. second aim outline progress understanding role pathogenesis.