Safety and technical success of methylene blue dye for lymphatic mapping in breast cancer

作者: Shaheen Zakaria , Tanya L. Hoskin , Amy C. Degnim

DOI: 10.1016/J.AMJSURG.2007.08.060

关键词:

摘要: Abstract Background We aimed to evaluate the safety and efficacy of methylene blue dye (MBD) for sentinel lymph node (SLN) mapping in breast cancer. Methods A total 398 patients undergoing 401 SLN biopsy procedures with MBD were retrospectively reviewed divided into 3 groups based on concentration location injection. Technical success complication rates compared. Results Overall technical was 99.7%. lowest group receiving full strength a peritumoral (74%) highest that received very dilute (1.25 mg/mL) subareolar (92%, P = .004). The rate first (21%) latter (2%, .0003). Conclusions Dilute successfully maps SLNs few complications.

参考文章(32)
Oliveira Neto AM, Neison M Duarte, WV Vicente, Fernanda Viaro, PR Evora, Methylene blue: an effective treatment for contrast medium-induced anaphylaxis. Medical Science Monitor. ,vol. 9, ,(2003)
A E Giuliano, R C Jones, M Brennan, R Statman, Sentinel lymphadenectomy in breast cancer. Journal of Clinical Oncology. ,vol. 15, pp. 2345- 2350 ,(1997) , 10.1200/JCO.1997.15.6.2345
Benjamin Stradling, Gerard Aranha, Sheryl Gabram, Adverse skin lesions after methylene blue injections for sentinel lymph node localization. American Journal of Surgery. ,vol. 184, pp. 350- 352 ,(2002) , 10.1016/S0002-9610(02)00945-5
Omgo E. Nieweg, Susanne H. Estourgie, Maartje C. van Rijk, Bin. B.R. Kroon, Rationale for superficial injection techniques in lymphatic mapping in breast cancer patients Journal of Surgical Oncology. ,vol. 87, pp. 153- 156 ,(2004) , 10.1002/JSO.20108
Rache Simmons, Sarmela Thevarajah, Meghan B. Brennan, Paul Christos, Michael Osborne, Methylene Blue Dye as an Alternative to Isosulfan Blue Dye for Sentinel Lymph Node Localization Annals of Surgical Oncology. ,vol. 10, pp. 242- 247 ,(2003) , 10.1245/ASO.2003.04.021
Amy C. Degnim, Kevin Oh, Vincent M. Cimmino, Kathleen M. Diehl, Alfred E. Chang, Lisa A. Newman, Michael S. Sabel, Is Blue Dye Indicated for Sentinel Lymph Node Biopsy in Breast Cancer Patients With a Positive Lymphoscintigram Annals of Surgical Oncology. ,vol. 12, pp. 712- 717 ,(2005) , 10.1245/ASO.2005.06.017
Leslie L. Montgomery, Alisa C. Thorne, Kimberly J. Van Zee, Jane Fey, Alexandra S. Heerdt, Mary Gemignani, Elisa Port, Jeanne Petrek, Hiram S. Cody, Patrick I. Borgen, Isosulfan blue dye reactions during sentinel lymph node mapping for breast cancer Anesthesia & Analgesia. ,vol. 95, pp. 385- 388 ,(2002) , 10.1097/00000539-200208000-00026
Pascale Dewachter, Claudie Mouton-Faivre, Philippe Tr??chot, Jean-Claude Lleu, Paul Michel Mertes, Severe anaphylactic shock with methylene blue instillation. Anesthesia & Analgesia. ,vol. 101, pp. 149- 150 ,(2005) , 10.1213/01.ANE.0000153497.60047.80
Walter D Blessing, Alan J Stolier, Stephen C Teng, John S Bolton, George M Fuhrman, A comparison of methylene blue and lymphazurin in breast cancer sentinel node mapping American Journal of Surgery. ,vol. 184, pp. 341- 345 ,(2002) , 10.1016/S0002-9610(02)00948-0