Nanoparticulated Honokiol Mitigates Cisplatin-Induced Chronic Kidney Injury by Maintaining Mitochondria Antioxidant Capacity and Reducing Caspase 3-Associated Cellular Apoptosis

摘要: Cisplatin is a potent anti-cancer drug, however, its accompanied organ-toxicity hampers clinical applications. Cisplatin-associated kidney injury known to result from accumulation in the renal tubule with excessive generation of reactive oxygen species. In this study, we encapsulated honokiol, natural lipophilic polyphenol constituent extracted Magnolia officinalis into nano-sized liposomes (nanosome honokiol) and examined vivo countering effects on cisplatin-induced injury. We observed that 5 mg/kg body weight. nanosome honokiol was lowest effective dosage efficiently restore functions cisplatin-treated animals. The improvement likely due maintenance cellular localization cytochrome c thus preserves mitochondria integrity their redox activity, which as consequence, reduced oxidative stress caspase 3-associated apoptosis. These improvements at level are later reflected reduction inflammation fibrosis. agreement our earlier vitro study showing protective cell lines, demonstrated further current nanosuspension-formulated provides against chronic damages vivo. Our findings not only benefit cisplatin-receiving patients side effects, but also provide potential alternative synergic solutions improve safety efficacy cisplatin treatment cancer patients.