Polymorphism of C4 with Special Reference to the Serological Determinants, Rodgers and Chido
作者： Carolyn M. Giles
DOI: 10.1007/978-3-642-71150-3_14
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摘要: The fourth component of complement (C4) in man has an important central role the classical pathway activation. It interacts with other components (C1, C2, C3) and binds covalently to antibody or antigen on cell surfaces. highly complex polymorphism is thought relate its diversity function (Porter 1983) limited, one reported exception (Mauff et al. 1983a), ∝ chain molecule more precisely C4d (∝2) fragment (Tilley 1978, Mevag 1981). Since contains structures involved activation, inactivation covalent binding C4 also 13 15 nucleotide sequence differences (Belt 1985), Porter suggests that probably exterior molecule.
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