Macrophages expressing the scavenger receptor CD163: a link between immune alterations of the gut and synovial inflammation in spondyloarthropathy.
作者： Dominique Baeten , Pieter Demetter , Claude A. Cuvelier , Elli Kruithof , Nancy Van Damme
DOI: 10.1002/PATH.1044
关键词:
摘要: The objective of this study was to investigate CD163+ macrophages in the synovial membrane patients with spondyloarthropathy (SpA). Immunohistochemistry performed on synovium 17 SpA and 18 rheumatoid arthritis (RA) patients, colonic biopsies 16 ten healthy controls, paired eight before after anti-TNFalpha therapy. Phenotype cytokine production were analysed by flow cytometry. increased lining sublining versus RA, as well lamina propria controls. number correlated C-reactive protein levels erythrocyte sedimentation rate. Paralleling increase CD163, HLA-DR SpA. In contrast, co-stimulatory molecules CD80 CD86 dendritic cell markers CD1a CD83 scarce synovium. Flow cytometry indicated that expressed high could produce vitro tumour necrosis factor alpha (TNFalpha) but not interleukin-10 (IL-10). Finally, therapy vivo induced a decrease sublining. conclusion, expressing scavenger receptor CD163 are mucosa SpA, highlighting relationship between joint gut disease. correlation inflammatory parameters, expression HLA-DR, TNFalpha IL-10, reduction support role for inflammation
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