Microbubble potentiated transcranial duplex ultrasound enhances IV thrombolysis in acute stroke

摘要: We studied whether 2 MHz transcranial color-coded duplex ultrasound (TCCD), combined with a second generation ECA, accelerate IV rtPA-thrombolysis in the acute phase of MCA stroke more than TCCD monitoring alone. Non-randomized patients undergoing and 2 MHZ-TCCD over 60 min, (N = 11) or without (N = 15) additional continuous ECA (5 ml, SonoVue®) perfusion, were compared. Recanalization was measured pre- post-thrombolysis thrombolysis brain ischemia (TIBI) grading system, clinical outcome assessed at admission 24 h after treatment using NIH scale (NIHSS). Patients who received improved their NIHSS significantly those only monitored (Mann–Whitney U = 48.0; P = 0.050), flow signal U = 40.0; P < 0.03). The results this pilot study show that IV-thrombolysis use addition to lead greater immediate improvement better signal.