Growth Hormone's Links to Cancer.

摘要: Several components of the GH axis are involved in tumor progression, and GH-induced intracellular signaling has been strongly associated with breast cancer susceptibility genome-wide association studies. In general population, high IGF-I levels low IGF-binding protein-3 within normal range development common malignancies, GH-IGF system exhibit correlations clinical, histopathological, therapeutic parameters patients. Despite promising findings preclinical studies, anticancer therapies targeting have led to disappointing results clinical trials. There is substantial evidence for some degree protection against several animal models patients genetic defects deficiency or resistance. contrast, link between excess risk acromegaly much less clear, screening a highly controversial issue. Recent studies shown that increased life expectancy who attain more deaths due age-related cancers. Replacement therapy hypopituitary adults short children be safe when no other factors malignancy present. Nevertheless, use survivors RASopathies, chromosomal breakage syndromes, DNA-repair disorders should carefully evaluated owing an recurrence, primary cancer, second neoplasia these individuals.