Background Intestinal 18F-FDG Uptake Is Related to Serum Lipid Profile and Obesity in Breast Cancer Patients

摘要: Background This study investigated the relationships between background intestinal uptake on 18F–FDG PET and cardio-metabolic risk (CMR) factors. Methods A total of 326 female patients that underwent to determine initial stage breast cancer were enrolled. None had history diabetes or hypertension. The was visually graded (low vs. high group) quantitatively measured using maximal standardized value (SUVmax). SUVmax 7 bowel segments (duodenum, jejunum, ileum, cecum, hepatic flexure, splenic descending colon-sigmoid junction) averaged for (TB SUVmax). Age, body mass index (BMI), fasting blood glucose level (BST), triglyceride (TG), cholesterol, density lipoprotein (HDL), low (LDL) considered CMR factors. diverse factors analyzed. Results The visual grades based classified 100 (30.7%) into group, while 226 (69.3%) group. Among factors, age (p = 0.004), BMI (p<0.001), TG (p<0.001) significantly different according grade uptake. Quantitative TB showed significant positive correlation with (r 0.203, p<0.001), 0.373, 0.338, cholesterol 0.148, p 0.008), LDL 0.143, 0.024) negative HDL -0.147, 0.022). Multivariate analysis indicated independent in both 0.027 0.023, respectively) 0.006 0.004, respectively). Conclusion Increased may suggest alteration lipid metabolism disease non-diabetic non-hypertensive patients.