Prostaglandin E2 and interleukin-1 levels in smokeless tobacco-induced oral mucosal lesions.

摘要: Inflammatory mediators released as a result of smokeless tobacco (ST)-induced irritation may play role in the development oral mucosal lesions at habitual placement sites ST users. The present study examined levels interleukin-1 (IL-1) and prostaglandin E2 (PGE2) ST-induced compared these to mediator clinically normal mucosa. Soft tissue biopsies were obtained from white alveolar non-placement 18 Fifteen non-tobacco using subjects also provided biopsies. IL-1 PGE2 recovered specimens, determined by enzyme immunoassay. Prostaglandin (pg/mg) lower both regions subjects, but values did not vary significantly between with 2.77 +/- 0.72 2.86 0.99 sites, respectively, users 7.31 3.84 Both alpha beta (p < 0.01) elevated (IL-1 = 25.56 4.00; 7.76 1.68) either 14.64 2.65; 1.63 0.72) or 12.84 2.60; 2.04 0.75). In view IL-1's keratinocyte proliferation its inflammatory effects, this cytokine contribute gingival alterations observed