In vitro effects of smokeless tobacco extract on tumor necrosis factor-α (TNF-α) and interleukin-1β (Il-1β) production, and on lymphocyte proliferation
作者： Seyed Ali Seyedroudbari , Manzoor M Khan
DOI: 10.1016/S0041-0101(97)00092-5
关键词: Splenocyte 、 Immunology 、 Lymphocyte 、 Cytokine 、 Lymphocyte proliferation 、 Smokeless tobacco 、 Cancer research 、 Interleukin 、 Proinflammatory cytokine 、 Medicine 、 Tumor necrosis factor alpha
摘要: The use of smokeless tobacco (moist snuff) products is associated with mucosal lesions, gingival recession, attachment loss, and oral cancer. Despite numerous reports on the general toxic effects extract, little information available regarding specific immune response. Inflammatory cytokines released as a result tobacco-induced irritation may play role in development lesions at habitual placement sites users. Consequently, purpose this study was to determine whether an aqueous extract (STE) affects secretion tumor necrosis factor-α (TNF-α), interleukin -1β (IL-1β), proliferation lymphocytes. A macrophage cell line (J774-A1) used measure STE (TNF-α) (IL-1β) secretion. Mouse splenocytes were assess lymphocyte proliferation. We found that low concentrations enhanced production both TNF-α IL-1β. Furthermore, similar mitogen-induced murine splenocyte Overall, these data suggest upregulated two key proinflammatory also induces
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