TNF impairs in vivo and in vitro natural killer (NK) susceptibility of B16 melanoma cells.
作者： G. PALMIERI , S. MORRONE , P.-L. LOLLINI , C. GIOVANNI , G. NICOLETTI
DOI: 10.1111/J.1365-3083.1992.TB02860.X
关键词: In vitro 、 Tumor necrosis factor alpha 、 Natural killer cell 、 MHC class I 、 Melanoma 、 In vivo 、 Cytokine 、 Immunology 、 Biology 、 Interferon gamma
摘要: Tumour necrosis factor alpha (TNF) is a multipotent cytokine which affects many biological properties of both normal and neoplastic cells. Here we show that treatment with TNF reduces B16-A melanoma cell susceptibility to in vivo- vitro-activated NK cell-mediated killing. This resistance associated an enhancement metastatic potential syngeneic mice, but not anti-asialo GM1-treated animals, further supporting the dependence TNF-induced ability. A significant increase MHC class I expression on murine cells observed after treatment. In all these effects interacts positively interferon gamma (IFN gamma). Taken together, results indicate negatively effectors vivo vitro. decreased may be related, at least part, enhanced antigens tumour
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A. Punturieri, A. Santoni, M. Piccoli, F. Velotti, L. Frati, R. B. Herberman, Overnight incubation of mouse spleen cells in recombinant IL-2 generates cytotoxic cells with NK characteristics from precursors enriched with or devoid of LGL. Clinical and Experimental Immunology. ,vol. 75, pp. 155- 160 ,(1989)
Jordan U. Gutterman, Elizabeth A. Grimm, Laurie B. Owen-Schaub, Synergy of Tumor Necrosis Factor and Interleukin 2 in the Activation of Human Cytotoxic Lymphocytes: Effect of Tumor Necrosis Factor α and Interleukin 2 in the Generation of Human Lymphokine-activated Killer Cell Cytotoxicity Cancer Research. ,vol. 48, pp. 788- 792 ,(1988)
K Kärre, H G Ljunggren, P Höglund, G Klein, C Ohlén, T Yamasaki, Afferent and efferent cellular interactions in natural resistance directed against MHC class I deficient tumor grafts. Journal of Immunology. ,vol. 140, pp. 671- 678 ,(1988)
P Scheurich, K Pfizenmaier, C Schlüter, M Krönke, Tumor necrosis factor enhances HLA-A,B,C and HLA-DR gene expression in human tumor cells. Journal of Immunology. ,vol. 138, pp. 975- 980 ,(1987)
K Kärre, G E Piontek, H G Ljunggren, K Taniguchi, R Kiessling, A Grönberg, G Klein, YAC-1 MHC class I variants reveal an association between decreased NK sensitivity and increased H-2 expression after interferon treatment or in vivo passage. Journal of Immunology. ,vol. 135, pp. 4281- 4288 ,(1985)
R. J. Chang, Sang He Lee, Effects of interferon-gamma and tumor necrosis factor-alpha on the expression of an Ia antigen on a murine macrophage cell line. Journal of Immunology. ,vol. 137, pp. 2853- 2856 ,(1986)
D W Bahler, G Dennert, J G Frelinger, C Landon, E M Lord, Lysis of a lung carcinoma by poly I:C-induced natural killer cells is independent of the expression of class I histocompatibility antigens. Journal of Immunology. ,vol. 140, pp. 2472- 2475 ,(1988)
P E Lipsky, D F Jelinek, Enhancement of human B cell proliferation and differentiation by tumor necrosis factor-alpha and interleukin 1. Journal of Immunology. ,vol. 139, pp. 2970- 2976 ,(1987)
K Taniguchi, K Nomoto, A Toshitani, Y Kawano, Synergistic defense system by cooperative natural effectors against metastasis of B16 melanoma cells in H-2-associated control: different behavior of H-2+ and H-2- cells in metastatic processes. Journal of Immunology. ,vol. 136, pp. 4729- 4734 ,(1986)
R C Burton, N Hanna, Definitive evidence that natural killer (NK) cells inhibit experimental tumor metastases in vivo. Journal of Immunology. ,vol. 127, pp. 1754- 1758 ,(1981)