Glycosyltransferase Genes: Applications to Medical Science
作者： Naoyuki TANIGUCHI , Soichi KOYOTA , Takeo TsuDA , Wenge WANG , Wei LI
DOI: 10.3164/JCBN.28.217
关键词:
摘要: Glycosylation represents a major posttranslational modification reaction of proteins and plays pivotal role in variety cellular events. N-Acetylglucosaminyltransferases III (GnT-III) V (GnT-V), α 1-6 fucosyltransferase are key enzymes the processing N-linked glycoproteins, heavily involved cancer progression metastasis. Very recently we also found that GnT-III is capable reducing or masking expression αGal epitope, which xenoantigen swine to human xenotransplantation. In this minireview focus on above glycosyltransferases metastasis as well
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