Aberrant nuclear beta-catenin expression in the spindle or corded cells in so-called corded and hyalinized endometrioid carcinomas. Another critical role of the unique morphological feature

摘要: Corded and hyalinized endometrioid carcinoma (CHEC), showing spindle and/or corded (SPICO) cells often in the background of stroma, is a rare variant uterine carcinomas. The aim our study was to explore status cell-adhesion molecules (beta-catenin, E-cadherin) CHECs survey whether immunostains for beta-catenin p53 can help distinguish from their morphological mimics: malignant mixed mullerian tumors (MMMTs) resembling ovarian sex-cord (UTROSCTs). Immunohistochemistry performed scored each element as follows: 0: negative, 1+: 30%. SPICO patterns were classified spindle/fusiform; 3, corded; 1, both; 2. components consisted 30%: 1. Five contained squamous components. In elements all CHECs, nuclear expression (score: 1+; 2+; 2, 3+; 3) complete loss membranous E-cadherin observed. contrast, comparable (sarcomatous ones eight MMMTs or sex-cord-like six UTROSCTs) showed no positivity beta-catenin. observed (64.7%), sarcomatous (87.5%), (50%) components, areas most notably diffuse intense staining. Sequence analysis PCR amplification products exon 3 gene revealed mutation cases, except two lacking represented on microdissected areas. Our results suggest that alterations beta-catenin/E-cadherin complex play critical role features. Immunostain promising approach distinguishing UTROSCTs.