Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein
作者： Xinfeng Zhang , Furong Qiu , Jian Jiang , Chenglu Gao , Yingzi Tan
DOI: 10.3109/00498254.2010.529180
关键词:
摘要: The absorption and transport mechanisms of berberine, palmatine, jateorhizine, coptisine were studied using a Caco-2 cells uptake model, with the addition cyclosporin A verapamil as P-glycoprotein (P-gp) inhibitors MK-571 multidrug resistance-associated protein 2 (MRP(2)) inhibitor. In experiment, all taken into cells, their uptakes increased in presence or verapamil. P(app) (AP-BL) was between 0.1 1.0 × 10(6) cm/sec for lower than (BL-AB). ER values >2. Cyclosporin both but decreased (BL-AB) coptisine; by >50%. had no influence on transmembrane coptisine. At concentration 1-100 μM, significant effects bidirection Rho123. Berberine, P-gp substrates; at range inhibitory P-gp.
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