IgA response to ESAT-6/CFP-10 and Rv2031 antigens varies in patients with culture-confirmed pulmonary tuberculosis, healthy Mycobacterium tuberculosis-infected and non-infected individuals in a tuberculosis endemic setting, Ethiopia.
作者： M. Legesse , G. Ameni , G. Medhin , G. Mamo , K. L. M. C. Franken
DOI: 10.1111/SJI.12080
关键词:
摘要: Little attention has been given to the role of antibodies against Mycobacterium tuberculosis (Mtb) infection. We have compared levels IgA and IgG ESAT-6/CFP-10 Rv2031c antigens in sera patients with culture-confirmed pulmonary (PTB), healthy Mtb-infected non-infected individuals endemic TB settings. Venous blood samples were collected from 166 study participants; separated assayed by an enzyme-linked immunosorbent assay (ELISA). QuantiFERON-TB Gold In-Tube (QFTGIT) was used for screening latent The mean optical density (OD) values Rv2031 significantly higher PTB (P < 0.001). OD also (P < 0.05). both cases individuals. There positive correlations (P < 0.05) between level IFN-γ induced QFTGIT serum subjects. This shows potential response discriminating clinical cases. Nevertheless, further well-designed cohort is needed fully realize full this diagnostic marker.
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