Embryo–maternal interactions at the implantation site: a delicate equilibrium

摘要: Blastocyst implantation and successful establishment of pregnancy require delicate interactions between the embryo maternal environment. During preimplantation, maternal/embryo communication is mediated by trophectoderm. In late luteal phase, physiological changes occur in endometrium to allow blastocyst implantation. The "window implantation" represents period maximum uterine receptivity for response signals from embryo, pregnancy-specific proteins are released serum a series morphological, biochemical immunological These systemic local modifications can be considered constitute "the recognition pregnancy". human hemochorial placenta arises primarily through proliferation, migration invasion its vasculature embryonic trophoblast. complex invasive processes accompanying controlled at embryo-maternal interface factors decidualized trophoblast itself. An inflammatory reaction proper immune survival development feto-placental unit. this review, we focus on tissues cellular mechanisms molecular involved closely regulated process