Short-term interferon-alfa therapy for acute hepatitis C: a randomized controlled trial.

摘要: Acute hepatitis C often progresses to chronic infection. We undertook a randomized controlled trial determine whether short-term therapy with interferon (IFN) during acute is effective in preventing the development of hepatitis. Thirty patients were into 1 2 treatment groups. IFN was initiated 8 weeks after onset early-intervention group and year observation late-intervention group. Short-term consisted natural IFN-alfa (6 million units) administered on consecutive days for period 4 weeks. Any signs recrudescence disease immediately followed by interval (3 times weekly 20 weeks). In group, associated sustained virological response 13 15 (87%). Follow-up both remaining (100%). The rate significantly higher (87%, alone, 100%, or without follow-up therapy) than (40%, 6 53%, therapy, P = .021 .006, respectively). conclusion, (4 weeks) may be satisfactory results, if at an early stage disease. (HEPATOLOGY 2004;39:1213–1219.)