One-pot microwave assisted preparation of pyrazoloquinazolinone libraries.
作者： Thomas E. Vasquez Jr. , Thomas Nixey , Balan Chenera , Vijay Gore , Michael D. Bartberger
DOI: 10.1023/B:MODI.0000006917.06401.48
关键词:
摘要: The novel solution phase synthesis of an array biologically relevant pyrazoloquinazolinones in a simple microwave driven, one pot procedure is described. Transformations are carried out good to excellent yield by condensation α-cyano-ketones and 2-hydrazino-benzoic acids. Subsequent irradiation affords with six points potential diversification. protocol described represents very attractive for the rapid generation arrays such functionalized cores, further demonstrating growing importance economic al chemistries that enable complexity genered this leading arena.
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