Selection intensity against deleterious mutations in RNA secondary structures and rate of compensatory nucleotide substitutions.

摘要: A two-locus model of reversible mutations with compensatory fitness interactions is presented; single are assumed to be deleterious but neutral in appropriate combinations. The expectation the time nucleotide substitutions calculated analytically for case tight linkage between sites. It shown that selection increases substitution dramatically when intensity Ns > 1, where N diploid population size and s coefficient. Computer simulations demonstrate recombination time, effect small weak. amount disequilibrium generated process also investigated. significant expected rare natural populations. applied mRNA secondary structure bicoid 3′ untranslated region Drosophila. concluded average against not likely much larger than 1.