Calotropis procera Root Extract Has the Capability to Combat Free Radical Mediated Damage
作者： Shashank Kumar , Ashutosh Gupta , Abhay K. Pandey
DOI: 10.1155/2013/691372
关键词:
摘要: The present study reports the antioxidant and membrane protective activities of Calotropis procera aqueous root extract using several in vitro assays along with determination phenolic as well flavonoid contents. Total phenol contents were 15.67 ± 1.52 mg propyl gallate equivalent/g 1.62 0.05 quercetin equivalent/g, respectively. UV-visual spectroscopic scanning indicated presence glycoside-linked tannins or flavonoids. exhibited appreciable reducing power signifying hydrogen donating potential. DPPH radical scavenging assay revealed substantial free activity (42–90%) extracts. Concentration dependent response was observed metal ion chelating (16–95%). Extracts also provided protection against iron induced lipid peroxidation rat tissue (liver, brain, kidney) homogenates. Comparatively better efficacy peroxidative damage liver (71%) followed by kidney (65%) brain (60%) tissues. Positive correlation between extract. Similarly strong positive ability percentage inhibition different demonstrated considerable C. extracts mediated oxidative damage.
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