Leptin stimulates aromatase in the growth plate: limiting catch-up growth efficiency.

摘要: Catch-up growth (CUG) in childhood is defined as periods of acceleration, after the resolution attenuation causes, bringing children back to their original trajectory. Sometimes, however, CUG incomplete, leading permanent deficit and short stature. The aim this study was investigate mechanisms that limit nutritional-CUG. Specifically, we focused on crosstalk between leptin, increased by re-feeding, sex hormones, which increase with age. In vivo studies were performed young male Sprague Dawley rats fed ad libitum or subjected 10/36 days 40% food restriction followed 90-120 re-feeding. vitro ATDC5 cells. Analyses mRNA protein levels done using qPCR Western blot, respectively. complete body weight humerus length animals food-restricted for 10 but not those 36 days. showed leptin significantly aromatase gene expression level well estrogen receptors a dose- time-dependent manner. effect direct mediated through MAPK/Erk, STAT3 PI3K pathways. plate suggests re-feeding during puberty may lead activity, consequently, irreversible premature epiphyseal closure. These results have important implications development novel treatment strategies stature children.