Effects of centrally administered anxiolytic compounds in animal models of anxiety.

摘要: Abstract The effect of intra-cerebrally infused compounds in animal models anxiety were reviewed. A large body evidence suggested that benzodiazepine agonists different brain regions—including areas the raphe, hypothalamus, periaqueductal gray, septum, hippocampus, and amygdala—produce reasonably consistent anxiolytic effects a variety models. However, regarding on 5-HT1A agonists, 5-HT2 compounds, 5-HT3 antagonists was somewhat less extensive, both anatomically behaviourally, more complex. For example, establishing receptor specificity for 5-HT ligand often complicated by lack `silent' and/or selective antagonists. Neuropeptides had significant anxiety, but these shown smaller number limited regions. Regardless tested, however, there seemed to be surprising double dissociations (brain site behavioural test). In fact some instances, fear reactions appeared controlled distinct sub-populations within particular parts limbic system. These results suggest neural control might analogous organization sensorimotor systems, i.e., is complex systems multiple, distributed, parallel pathways.