Anti-acth antibodies and use thereof

摘要: The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Another embodiment of this relates the described herein, comprising sequences VH, VL and/or CDR polypeptides polynucleotides encoding them. also contemplates conjugates anti-ACTH conjugated one or more functional detectable moieties. further methods making said thereof. Embodiments pertain use diagnosis, assessment, prevention treatment diseases disorders associated with ACTH, such as Cushing's Disease, Syndrome, Parkinson's disease, obesity, diabetes, sleep depression, anxiety disorders, cancer, muscle atrophy, hypertension, hyperinsulinemia, cognitive dysfunction, Alzheimer's galactorrhea, stress related conditions, cardiac metabolic syndrome, hyperaldosteronism, Conn's syndrome familial hyperaldosteronism.