作者: T.C. Neymann , S. Wegerhoff , S. Engell
DOI: 10.3182/20100707-3-BE-2012.0037
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摘要: Abstract The correct description of cell cultures is vital for the understanding underlying processes and optimisation production processes. brewer's yeast Saccharomyces cerevisiae a commonly used well explored organism amino acids, antibiotics, recombinant proteins, others. In this paper, an existing single model cycle S. extended in order to correctly describe mass, age, distributions culture. For this, aging process has been integrated into model. can be gain insight distribution mutant populations. Also, it regarded as first step development strategies where secretion rates products vary over cycle.