Towards understanding of the complex structure of growing yeast populations.

摘要: In a growing Saccharomyces cerevisiae population, cell size is finely modulated according to both the chronological and genealogical ages. This generates complex heterogeneous structure typical of budding yeast populations. recent years, there has been interest in developing mathematical models capable faithfully describing population dynamics at single level. A multistaged morphologically structured model lately proposed based on balance theory. The was able describe generation starting from sub-population daughter unbudded cells. this work, which aims validating model, simulated experiment performed by following release homogeneous biparametric flow cytometric approach allowed us analyse time course joint distribution DNA protein contents level; gave insights into coupling between growth cycle progression that generated final structure. comparison experimental distributions revealed strong agreement for some unexpected features as well. Therefore, can be considered validated extendable more situations.