Yeast as a model for medical and medicinal research

作者: Willem H. Mager , Joris Winderickx

DOI: 10.1016/J.TIPS.2005.03.004

关键词:

摘要: In the past, studies using yeast Saccharomyces cerevisiae enabled major breakthroughs in understanding of basic cellular and molecular processes. Today, use is undergoing a "rebirth" both fundamental applied research. Indeed, advances technology have paved way for variety new genome-wide screening approaches. Experimental strategies aim to unravel disease-related events discover novel medicinal compounds. this article, impact as an experimental tool summarized high-throughput screenings pharmacological purposes evaluated. The recently promising approach so-called humanized systems also discussed.

参考文章(63)
Mary J. Cismowski, Aya Takesono, Chienling Ma, Stephen M. Lanier, Emir Duzic, Identification of modulators of mammalian G-protein signaling by functional screens in the yeast Saccharomyces cerevisiae. Methods in Enzymology. ,vol. 344, pp. 153- 168 ,(2002) , 10.1016/S0076-6879(02)44712-X
Dieter Edbauer, Edith Winkler, Joerg T. Regula, Brigitte Pesold, Harald Steiner, Christian Haass, Reconstitution of γ-secretase activity Nature Cell Biology. ,vol. 5, pp. 486- 488 ,(2003) , 10.1038/NCB960
Guri Giaever, Daniel D. Shoemaker, Ted W. Jones, Hong Liang, Elizabeth A. Winzeler, Anna Astromoff, Ronald W. Davis, Genomic profiling of drug sensitivities via induced haploinsufficiency. Nature Genetics. ,vol. 21, pp. 278- 283 ,(1999) , 10.1038/6791
Igor Stagljar, Stephan te Heesen, Detecting interactions between membrane proteins in vivo using chimeras. Methods in Enzymology. ,vol. 327, pp. 190- 198 ,(2000) , 10.1016/S0076-6879(00)27276-5
Piotr Zabrocki, Klaartje Pellens, Thomas Vanhelmont, Tom Vandebroek, Gerard Griffioen, Stefaan Wera, Fred Van Leuven, Joris Winderickx, Characterization of α-synuclein aggregation and synergistic toxicity with protein tau in yeast FEBS Journal. ,vol. 272, pp. 1386- 1400 ,(2005) , 10.1111/J.1742-4658.2005.04571.X
Chandra L. Tucker, Stanley Fields, A yeast sensor of ligand binding. Nature Biotechnology. ,vol. 19, pp. 1042- 1046 ,(2001) , 10.1038/NBT1101-1042
Ami Aronheim, Ras signaling pathway for analysis of protein-protein interactions. Methods in Enzymology. ,vol. 332, pp. 260- 270 ,(2001) , 10.1016/S0076-6879(01)32208-5
Ajay Jain, Kurt Jarnagin, Joe Couto, Stuart Tugendreich, David Morgans, Elaine Yeh, Dongxu Sun, Hieu Nguyen, Suzana Tulac, Teri Melese, Ed Perkins, Silke Thode, Homa Tavana, Allen Nguyen, Michelle Francesco, Peter Barthmaier, Novel Inhibitors of Poly(ADP-ribose) Polymerase/PARP1 and PARP2 Identified Using a Cell-based Screen in Yeast Cancer Research. ,vol. 61, pp. 4175- 4183 ,(2001)
Leland H. Hartwell, NOBEL LECTURE: Yeast and Cancer Bioscience Reports. ,vol. 22, pp. 373- 394 ,(2002) , 10.1023/A:1020918107706
Graham Ladds, Kevin Davis, Edward W. Hillhouse, John Davey, Modified yeast cells to investigate the coupling of G protein-coupled receptors to specific G proteins Molecular Microbiology. ,vol. 47, pp. 781- 792 ,(2003) , 10.1046/J.1365-2958.2003.03336.X