SFP1 is involved in cell size modulation in respiro-fermentative growth conditions.

摘要: Saccharomyces cerevisiae grows fast on glucose, while growth slows down ethanol as cells move from glucose fermentation to oxidative metabolism. The type of carbon source influences both the specific rate and cell cycle progression, well size. Yeast grown have a larger size than ethanol. Here, we analysed behaviour sfp1 null mutant during balanced transitory states in batch response changes medium sources. In screening for mutants affected at Start, SFP1 has been identified gene whose deletion caused one smallest whi phenotype. Findings presented this work indicate that reduction is not only consequence reduced but it tightly linked cellular product required sustain increase rRNA protein content wild-type takes place respiro-fermentative conditions, seems dispensable non-fermentable It follows growing and, noticeably, former enter S phase with critical higher latter. These features, combined role Sfp1p transcriptional factor, suggest could be an important element control modulated by nutrients. Copyright © 2005 John Wiley & Sons, Ltd.