Granulocytes Obtained from HL-60 Cells by Retinoic Acid Treatment Behave Abnormally in Hematopoietic Regulation — Possible Consequences for Differentiation Induction Treatment of Leukemia
作者： W. R. Paukovits , J. B. Paukovits , O. D. Laerum
DOI: 10.1007/978-1-4612-4594-0_7
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摘要: Tumor stem cells, both in hematopoietic and solid neoplasms give rise to differentiated or fully maturated end stage cells at a rate significantly below that of corresponding normal tissues (1,2,3). This aspect malignancy seems not be completely irreversible. In several experimental systems chemical induction differentiation has been accomplished vitro (see compilation ref. 4). Based on such observations the emerging concept therapy was tested vivo animal (5,6,7,8,9).
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