Hierarchical down-modulation of hemopoietic growth factor receptors

作者: Francesca Walker , Nicos A Nicola , Donald Metcalf , Antony W Burgess

DOI: 10.1016/0092-8674(85)90032-7

关键词: Cell biologyHaematopoiesisEndocrinologyInternal medicineBiologyBone marrowColony-stimulating factorCell surface receptorReceptorGrowth factor receptorProgenitor cellCellular differentiationGeneral Biochemistry, Genetics and Molecular Biology

摘要: Abstract Granulocytes and macrophages can be produced in vitro when progenitor cells from mouse bone marrow are stimulated by any of four distinct colony stimulating factors, Multi-CSF (IL-3), GM-CSF, G-CSF, M-CSF (CSF-1). At 0°C the CSFs do not cross-complete for binding to cells, indicating that each has a specific cell surface receptor. However, at 21°C or 37°C, inhibits other three GM-CSF G-CSF M-CSF. Rather than competing directly receptor binding, Multi-CSF, their own induces down-modulation (and thus activation) CSF receptors 37°C. The pattern potency activity exhibited type parallels its biological activity. We propose model which interactions explained ability down-modulate activate lineage-specific receptors.

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