Synergism between smoking and alcohol consumption with respect to serum gamma-glutamyltransferase†‡

摘要: There is increasing evidence that serum levels of the liver enzyme gamma-glutamyltransferase (γ-GT) are an important predictor incidence and mortality various diseases. Apart from alcohol consumption, body mass index smoking have been found to be associated with levels, but little known about potential interactions these factors. The aim this study was assess individual joint impact consumption on γ-GT, particular attention differences by sex. based data 8465 subjects aged 50 74 years, obtained at baseline examination ESTHER study, a large population-based cohort in Germany. Exposure–outcome relationships were assessed women men, adjusting for confounders multiple regression. In both sexes, moderate heavy (100+ g/week) 1.7-fold increased odds elevated γ-GT (>50 IU/L) reference nonsmoking abstainers, whereas itself unrelated γ-GT. However, when present combination smoking, ratios (95% CI) 2.9 (1.1–7.6) 3.8 (2.2–6.6) men (test interaction between smoking: Pfemales = 0.12, Pmales 0.0017). Conclusion: Our results support notion detrimental cigarette as determinants especially men. (HEPATOLOGY 2009.)