Mechanical Stretch Modulates MicroRNA 21 Expression, Participating in Proliferation and Apoptosis in Cultured Human Aortic Smooth Muscle Cells
作者： Jian tao Song , Bo Hu , Hai yan Qu , Cheng long Bi , Xiao zhen Huang
DOI: 10.1371/JOURNAL.PONE.0047657
关键词:
摘要: Objectives Stretch affects vascular smooth muscle cell proliferation and apoptosis, several responsible genes have been proposed. We tested whether the expression of microRNA 21 (miR-21) is modulated by stretch involved in stretch-induced apoptosis human aortic cells (HASMCs).
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core.ac.uk 参考文章(35)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
Kuei-Chun Wang, Lana Xia Garmire, Angela Young, Phu Nguyen, Andrew Trinh, Shankar Subramaniam, Nanping Wang, John YJ Shyy, Yi-Shuan Li, Shu Chien, Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 3234- 3239 ,(2010) , 10.1073/PNAS.0914825107
Yunhui Cheng, Chunxiang Zhang, MicroRNA-21 in Cardiovascular Disease Journal of Cardiovascular Translational Research. ,vol. 3, pp. 251- 255 ,(2010) , 10.1007/S12265-010-9169-7
Nobuhiko JOKI, Shinya KANAME, Masao HIRAKATA, Yuichi HORI, Tetsu YAMAGUCHI, Toshiro FUJITA, Tetsuo KATOH, Kiyoshi KUROKAWA, Tyrosine-Kinase Dependent TGF-.BETA. and Extracellular Matrix Expression by Mechanical Stretch in Vascular Smooth Muscle Cells. Hypertension Research. ,vol. 23, pp. 91- 99 ,(2000) , 10.1291/HYPRES.23.91
Daniel G. Sedding, Ulrike Seay, Ludger Fink, Matthias Heil, Wolfgang Kummer, Harald Tillmanns, Ruediger C. Braun-Dullaeus, Mechanosensitive p27Kip1 Regulation and Cell Cycle Entry in Vascular Smooth Muscle Cells Circulation. ,vol. 108, pp. 616- 622 ,(2003) , 10.1161/01.CIR.0000079102.08464.E2
Xiaomei Qin, Xiaohong Wang, Ying Wang, Zhihui Tang, Qinghua Cui, Jianzhong Xi, Yi-Shuan J. Li, Shu Chien, Nanping Wang, None, MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 3240- 3244 ,(2010) , 10.1073/PNAS.0914882107
Jizhong Cheng, Jiqiang Zhang, Aksam Merched, Liping Zhang, Ping Zhang, Luan Truong, Aladin M. Boriek, Jie Du, Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin αVβ3 and stablization of PINCH-1 Journal of Biological Chemistry. ,vol. 282, pp. 34268- 34275 ,(2007) , 10.1074/JBC.M703115200
Baogen Y. Su, Kimberly M. Shontz, Nicholas A. Flavahan, Philip T. Nowicki, The effect of phenotype on mechanical stretch-induced vascular smooth muscle cell apoptosis. Journal of Vascular Research. ,vol. 43, pp. 229- 237 ,(2006) , 10.1159/000091102
Yuri D’Alessandra, Giulio Pompilio, Maurizio C. Capogrossi, MicroRNAs and myocardial infarction Current Opinion in Cardiology. ,vol. 27, pp. 228- 235 ,(2012) , 10.1097/HCO.0B013E3283522052
Xiaoqian Wu, Jizhong Cheng, Ping Li, Min Yang, Shulan Qiu, Peiqing Liu, Jie Du, Mechano-Sensitive Transcriptional Factor Egr-1 Regulates Insulin-Like Growth Factor-1 Receptor Expression and Contributes to Neointima Formation in Vein Grafts Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 30, pp. 471- 476 ,(2010) , 10.1161/ATVBAHA.109.184259