Association between brain temperature and dentate field potentials in exploring and swimming rats

作者: E Moser , I Mathiesen , P Andersen

DOI: 10.1126/SCIENCE.8446900

关键词:

摘要: Attempts to correlate behavioral learning with cellular changes, such as increased synaptic efficacy, have often relied on extracellular potentials an index of enhanced strength. A recent example is the enlarged excitatory field in dentate gyrus rats that are spatial relations by exploration. The altered hippocampal do not reflect learning-specific changes but result from a concomitant rise brain temperature caused associated muscular effort. Enhanced followed both passive and active heating were linearly related temperature. These temperature-related effects may mask any learning-induced potential.

参考文章(17)
EL Hargreaves, DP Cain, CH Vanderwolf, Learning and behavioral-long-term potentiation: importance of controlling for motor activity. The Journal of Neuroscience. ,vol. 10, pp. 1472- 1478 ,(1990) , 10.1523/JNEUROSCI.10-05-01472.1990
R.M. Abrams, J.A.J. Stolwijk, H.T. Hammel, H. Graichen, Brain temperature and brain blood flow in unanesthetized rats Life Sciences. ,vol. 4, pp. 2399- 2410 ,(1965) , 10.1016/0024-3205(65)90295-X
Steven J. Schiff, George G. Somjen, The effects of temperature on synaptic transmission in hippocampal tissue slices. Brain Research. ,vol. 345, pp. 279- 284 ,(1985) , 10.1016/0006-8993(85)91004-2
Patricia E. Sharp, Bruce L. McNaughton, Carol A. Barnes, Exploration-dependent modulation of evoked responses in fascia dentata: Fundamental observations and time course Psychobiology. ,vol. 17, pp. 257- 269 ,(1989) , 10.1007/BF03337777
A. L. Hodgkin, B. Katz, The effect of temperature on the electrical activity of the giant axon of the squid The Journal of Physiology. ,vol. 109, pp. 240- 249 ,(1949) , 10.1113/JPHYSIOL.1949.SP004388
Christopher J. Gordon, Thermal biology of the laboratory rat. Physiology & Behavior. ,vol. 47, pp. 963- 991 ,(1990) , 10.1016/0031-9384(90)90025-Y
B Katz, R Miledi, The effect of temperature on the synaptic delay at the neuromuscular junction. The Journal of Physiology. ,vol. 181, pp. 656- 670 ,(1965) , 10.1113/JPHYSIOL.1965.SP007790