Multifunctional drug carriers comprised of mesoporous silica nanoparticles and polyamidoamine dendrimers based on layer-by-layer assembly
作者： Xiubin Xu , Shaoyu Lü , Chunmei Gao , Xiao Bai , Chen Feng
DOI: 10.1016/J.MATDES.2015.09.069
关键词:
摘要: Abstract To overcome serious limitations encountered by mesoporous silica nanoparticle (MSN) and dendrimers used alone, to further enhance their performance for application in cancer treatment, multifunctional nanoparticles as nanocarriers were prepared layer-by-layer assembly method, with biocompatible Polyamidoamine (PAMAM) chondroitin sulfate (CS). Due being incorporated MSN, PAMAM can avoid the fast clearance. Attributing multilayer coating of CS, possess self-fluorescent property, avoiding use fluorescent labels enabling release drugs responded pH. Furthermore, sulfate, a natural polysaccharide found bone, cartilage, connective tissue, be served linking points bring together, delivery via its targeting ability.
elsevier.com
sci-hub.se 参考文章(41)
Deepak Pathania, Mamta Kumari, Vinod Kumar Gupta, Fabrication of ZnS–cellulose nanocomposite for drug delivery, antibacterial and photocatalytic activity Materials & Design. ,vol. 87, pp. 1056- 1064 ,(2015) , 10.1016/J.MATDES.2015.08.103
Vladimir S. Talanov, Celeste A. S. Regino, Hisataka Kobayashi, Marcelino Bernardo, Peter L. Choyke, Martin W. Brechbiel, Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging. Nano Letters. ,vol. 6, pp. 1459- 1463 ,(2006) , 10.1021/NL060765Q
Adem Yildirim, Erol Ozgur, Mehmet Bayindir, Impact of mesoporous silica nanoparticle surface functionality on hemolytic activity, thrombogenicity and non-specific protein adsorption Journal of Materials Chemistry B. ,vol. 1, pp. 1909- 1920 ,(2013) , 10.1039/C3TB20139B
Adem Yildirim, Gokcen Birlik Demirel, Rengin Erdem, Berna Senturk, Turgay Tekinay, Mehmet Bayindir, Pluronic polymer capped biocompatible mesoporous silica nanocarriers. Chemical Communications. ,vol. 49, pp. 9782- 9784 ,(2013) , 10.1039/C3CC45967E
Chuanming Yu, Chunmei Gao, Shaoyu Lü, Chen Chen, Yinjuan Huang, Mingzhu Liu, Redox-responsive shell-sheddable micelles self-assembled from amphiphilic chondroitin sulfate-cholesterol conjugates for triggered intracellular drug release Chemical Engineering Journal. ,vol. 228, pp. 290- 299 ,(2013) , 10.1016/J.CEJ.2013.04.083
Paul J. G. Goulet, David S. dos Santos,, Ramón A. Alvarez-Puebla, Osvaldo N. Oliveira,, Ricardo F. Aroca, Surface-enhanced raman scattering on dendrimer/metallic nanoparticle layer-by-layer film substrates. Langmuir. ,vol. 21, pp. 5576- 5581 ,(2005) , 10.1021/LA050202E
Lara Gushulak, Richard Hemming, Dianna Martin, Volkan Seyrantepe, Alexey Pshezhetsky, Barbara Triggs-Raine, Hyaluronidase 1 and β-Hexosaminidase Have Redundant Functions in Hyaluronan and Chondroitin Sulfate Degradation Journal of Biological Chemistry. ,vol. 287, pp. 16689- 16697 ,(2012) , 10.1074/JBC.M112.350447
Ajay J. Khopade, Frank Caruso, Stepwise Self-Assembled Poly(amidoamine) Dendrimer and Poly(styrenesulfonate) Microcapsules as Sustained Delivery Vehicles Biomacromolecules. ,vol. 3, pp. 1154- 1162 ,(2002) , 10.1021/BM025562K
Katsuhiko Ariga, Yuri M. Lvov, Kohsaku Kawakami, Qingmin Ji, Jonathan P. Hill, Layer-by-layer self-assembled shells for drug delivery. Advanced Drug Delivery Reviews. ,vol. 63, pp. 762- 771 ,(2011) , 10.1016/J.ADDR.2011.03.016
Cameron C Lee, John A MacKay, Jean MJ Fréchet, Francis C Szoka, None, Designing dendrimers for biological applications Nature Biotechnology. ,vol. 23, pp. 1517- 1526 ,(2005) , 10.1038/NBT1171