Fibrous CaF2:Yb,Er@SiO2-PAA ‘tumor patch’ with NIR-triggered and trackable DOX release
作者： Zhen Xia , Yike Fu , Tongxu Gu , Yangyang Li , Heng Liu
DOI: 10.1016/J.MATDES.2017.01.022
关键词:
摘要: Abstract Smart localized drug delivery systems (LDDSs), with stimuli-responsive properties, offer tremendous opportunity for personalized cancer chemotherapy. In our work, an implantable ‘tumor patch’, consisting of upconversion (UC) photoluminescent CaF2:Yb,Er nanoparticles embedded within silica nanofibers (CaF2:Yb,Er@SiO2), was designed and synthesized doxorubicin (DOX) delivery. DOX loading capacity the fiber mesh remarkably enhanced assist polyacrylic acid (PAA) functionalization. PAA modified CaF2:Yb,Er@SiO2 presented highly corresponding optical response to release kinetics. Accelerated in acidic condition induced more rapid increase spectral intensity ratio green red emission (I550/I660), vice versa. More importantly, under irradiation NIR (808 nm) laser, kinetics consequently in-vitro anti-cancer efficacy were enhanced. This study has thus offered another new LDDS NIR-triggered monitored protocols tumor
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