Topographical diversity of common skin microflora and its association with skin environment type: An observational study in Chinese women.

摘要: This study evaluated cutaneous microbial distribution, and co-occurrence at different body sites skin environments in Chinese women (39.6 ± 11.9 years, N = 100) during the winter season. Microbial distribution (Propionibacterium acnes, Staphylococcus aureus, epidermidis, Lactobacillus, Pseudomonadaceae, Malassezia furfur), association with biomarkers (antimicrobial peptides: LL-37, β-defensins [HBD-2, HBD-3]), claudin-1) biophysical parameters (transepidermal water loss, pH, scaliness roughness, sebum hydration levels) were also determined. Skin (glabella [GL], hand-back [HB], interdigital web-space [IS], antecubital fossa [AF], volar forearm [VF], back [BA]) classified as normal, oily or dry based on two-step cluster analysis exposed unexposed (uncovered covered by clothes, respectively) seasonal apparel. Pseudomonadaceae aureus had highest lowest detection rate respectively all sites. Cluster identified ‘normal’ (HB, BA, AF, VF), ‘dry’ (IS) ‘oily’ (GL). Bacterial alpha diversity was higher IS, GL) compared (BA, AF VF). Co-occurrence of any other five microorganisms lower versus normal skin. exposure, biophysical/barrier profile found to be associated bacterial co-occurrence.