Pathogenesis of African swine fever virus in Ornithodoros ticks.

摘要: African swine fever virus (ASFV) is the only known DNA arbovirus and sole member of family Asfarviridae. It causes a lethal, hemorrhagic disease in domestic pigs. ASFV enzootic sub-Saharan Africa maintained sylvatic cycle by infecting both wild members Suidae (e.g. warthogs) argasid tick Ornithodoros porcinus porcinus. The pathogenesis O. ticks characterized low infectious dose, lifelong infection, efficient transmission to pigs ticks, mortality until after first oviposition. warthogs an inapparent infection with transient, viremic titers. Thus probably constitute most important natural vector ASFV, although mammalian hosts are required for maintenance cycle. mechanism from through infected feeding on In addition porcinus, number North American, Central American Caribbean species have been shown be potential vectors ASFV.