PKC-θ exists in an oxidized inactive form in naive human T cells

摘要: PKC-θ plays a central role in TCR-induced IL-2 production and T-cell proliferation. The aim of the present study was to analyse how is regulated human T cells during activation differentiation. We show that found high-molecular disulfide-linked complex naive cells, most likely inactive this form. In parallel with accumulation major redox regulators, glutathione thioredoxin, gradually reduced 82 kDa active form activation. demonstrate recruited plasma membrane dependent requires de novo synthesis glutathione. This first shows activity by intracellular state, an cells. Our observations underscore existence differences TCR signaling versus primed